The issue of the difference between male and female inheritance in verse 11 of Surah Nisa has always been one of the centers of controversy in Islamic studies. Part of these challenges is caused by neglecting the variety of levels of explanation in Quranic interpretations. The current research, with the descriptive-analytical method and the comparative approach between the interpretations of the both parties (Sunni and Shia), deals with the typology of explanations of the wisdom of this difference with the aim of analyzing and solving the challenge. The findings show that the commentators have explained the wisdom of this ruling on three levels: duty-oriented with an emphasis on men's financial responsibilities; education-oriented focusing on the educational aspect of consciously accepting the divine decree; and system-oriented in the framework of the legal-social structure of Islam. The results show that the difference of opinions of the commentators is not caused by the basic conflict, but is the result of focusing on different levels of analysis. In fact, these explanations are complementary to each other, and only with a comprehensive look at these three levels can we achieve a coherent understanding of the wisdom or rationale of legislating inheritance shares.